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KMID : 0613820220320010070
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Journal of Life Science
2022 Volume.32 No. 1 p.70 ~ p.77
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Effects of Endocrine Disrupting Chemicals on the Nervous System
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Shin Hyun-Seung
Wi Jae-Ho
Lee Seung-Hyun
Choi Soo-Min
Jung Eui-Man
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Abstract
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Endocrine disrupting chemicals (EDCs) have been attracting significant attention in modern society, owing to the increased incidence rate of various diseases along with population growth. EDCs are found in many commercial products, including some plastic bottles and containers, detergents, liners of metal food cans, flame retardants, food, toys, cosmetics, and pesticides. EDCs have a hormonal effect on the human body, which disrupts the endocrine system, notably affecting sexual differentiation and normal reproduction, and can trigger cancer as well. Recently, the association between neurological diseases and EDCs has become a hot topic of research in the field of neuroscience. Considering that EDCs negatively affect not only neuronal proliferation and neurotransmission but also the formation of the neuronal networks, EDCs may induce neurodevelopmental disorders, such as autism spectrum disorders and attention-deficit/hyperactivity disorder as well as neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease. In light of these potentially deleterious outcomes, important efforts have been underway to minimize the exposure to EDCs through appropriate regulations and policies around the world, but chemicals that have not yet been associated with endocrine disrupting properties are still in wide use. Therefore, more epidemiological investigations and research are needed to fully understand the effects of EDCs on the nervous system.
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KEYWORD
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Endocrine disrupting chemicals, neurological diseases, neurodevelopmental disorders, neurodegenerative diseases, nervous system
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